Version 5.4
Homo sapiens Gene: CCRL1
Summary
InnateDB Gene IDBG-57099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCRL1
Gene Name chemokine (C-C motif) receptor-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129048
Encoded Proteins
IDBP-57101
chemokine (C-C motif) receptor-like 1
IDBP-477165
chemokine (C-C motif) receptor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:132597237-132618967
Strand Forward strand
Band q22.1
Transcripts
ENST00000249887 ENSP00000249887
ENST00000509820 ENSP00000425557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0019956 chemokine binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079355
View Gene Order
ENSBTAG00000019577
Not yet available
Pathways
NETPATH
REACTOME
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598856 Hs.743547
RefSeq NM_016557 NM_178445
HUGO
OMIM
CCDS CCDS3075
HPRD 07298
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca