Homo sapiens Gene: TF
Summary
InnateDB Gene IDBG-57280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TF
Gene Name transferrin
Synonyms PRO1557; PRO2086; TFQTL1;
Species Homo sapiens
Ensembl Gene ENSG00000091513
Encoded Proteins
transferrin
transferrin
transferrin
transferrin
transferrin
transferrin
transferrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:133745956-133779006
Strand Forward strand
Band q22.1
Transcripts
ENST00000402696 ENSP00000385834
ENST00000414694 ENSP00000401505
ENST00000466911 ENSP00000417468
ENST00000474287
ENST00000482271 ENSP00000419338
ENST00000460531
ENST00000485977 ENSP00000418716
ENST00000494430 ENSP00000418396
ENST00000493011
ENST00000475382
ENST00000498622
ENST00000461695 ENSP00000419714
ENST00000462495
ENST00000467842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008199 ferric iron binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001895 retina homeostasis
GO:0002576 platelet degranulation
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0033572 transferrin transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005905 coated pit
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0034774 secretory granule lumen
GO:0045178 basal part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Transferrin endocytosis and recycling pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
EPHB forward signaling
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518267 Hs.729019 Hs.732443
RefSeq NM_001063
HUGO
OMIM
CCDS CCDS3080
HPRD 01811
IMGT
EMBL
GenPept
RNA Seq Atlas