Homo sapiens Gene: CKM
Summary
InnateDB Gene IDBG-57300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKM
Gene Name creatine kinase, muscle
Synonyms CKMM; M-CK;
Species Homo sapiens
Ensembl Gene ENSG00000104879
Encoded Proteins
creatine kinase, muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45306414-45322977
Strand Reverse strand
Band q13.32
Transcripts
ENST00000221476 ENSP00000221476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004111 creatine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006600 creatine metabolic process
GO:0016310 phosphorylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046314 phosphocreatine biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Creatine metabolism pathway
KEGG
Arginine and proline metabolism pathway
INOH
Arginine Proline metabolism pathway
PID BIOCARTA
PID NCI
Regulation of retinoblastoma protein
Cross-References
SwissProt P06732
TrEMBL
UniProt Splice Variant
Entrez Gene 1158
UniGene Hs.334347 Hs.742410
RefSeq NM_001824 XM_005258497
HUGO HGNC:1994
OMIM 123310
CCDS CCDS12659
HPRD 00426
IMGT
EMBL AC005781 AY585238 BC007462 BT006793 M14780 M16440 M21488 M21489 M21490 M21491 M21492 M21493 M21494
GenPept AAA52025 AAA52026 AAA96609 AAC62841 AAH07462 AAP35439 AAS79321
RNA Seq Atlas 1158