Version 5.4
Homo sapiens Gene: CKM
Summary
InnateDB Gene IDBG-57300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKM
Gene Name creatine kinase, muscle
Synonyms CKMM; M-CK
Species Homo sapiens
Ensembl Gene ENSG00000104879
Encoded Proteins
IDBP-57302
creatine kinase, muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45306414-45322977
Strand Reverse strand
Band q13.32
Transcripts
ENST00000221476 ENSP00000221476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004111 creatine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006600 creatine metabolic process
GO:0016310 phosphorylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046314 phosphocreatine biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030399
View Gene Order
ENSBTAG00000013921
Not yet available
Pathways
NETPATH
REACTOME
REACT_813
Creatine metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
Cross-References
SwissProt P06732
TrEMBL
UniProt Splice Variant
Entrez Gene 1158
UniGene Hs.334347 Hs.742410
RefSeq NM_001824 XM_005258497
HUGO HGNC:1994
OMIM 123310
CCDS CCDS12659
HPRD
IMGT
EMBL AC005781 AY585238 BC007462 BT006793 M14780 M16440 M21488 M21489 M21490 M21491 M21492 M21493 M21494
GenPept AAA52025 AAA52026 AAA96609 AAC62841 AAH07462 AAP35439 AAS79321
RNA Seq Atlas 1158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca