Homo sapiens Gene: KCNMB1
Summary
InnateDB Gene IDBG-57308.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB1
Gene Name potassium large conductance calcium-activated channel, subfamily M, beta member 1
Synonyms BKbeta1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; SLO-BETA; slo-beta-1;
Species Homo sapiens
Ensembl Gene ENSG00000145936
Encoded Proteins
potassium large conductance calcium-activated channel, subfamily M, beta member 1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:170374671-170389677
Strand Reverse strand
Band q35.1
Transcripts
ENST00000274629 ENSP00000274629
ENST00000521859 ENSP00000427940
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015269 calcium-activated potassium channel activity
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0051592 response to calcium ion
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Ca2+ activated K+ channels pathway
Neuronal System pathway
cGMP effects pathway
Platelet homeostasis pathway
Potassium Channels pathway
Hemostasis pathway
Nitric oxide stimulates guanylate cyclase pathway
KEGG
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q16558
TrEMBL
UniProt Splice Variant
Entrez Gene 3779
UniGene Hs.484099
RefSeq NM_004137
HUGO HGNC:6285
OMIM 603951
CCDS CCDS4373
HPRD 10358
IMGT
EMBL AF026002 AK313979 AY044441 AY515264 BC025707 CH471062 U25138 U38907 U42600 U42601 U42602 U42603 U61536 U61537
GenPept AAA81327 AAB02394 AAB16825 AAB16826 AAB16827 AAB61396 AAB61397 AAB88805 AAH25707 AAK95827 AAS20193 BAG36693 EAW61474
RNA Seq Atlas 3779