InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNMB1

Summary

InnateDB Protein

IDBP-57310.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNMB1

Protein Name

potassium large conductance calcium-activated channel, subfamily M, beta member 1

Synonyms

BKbeta1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; SLO-BETA; slo-beta-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000274629

InnateDB Gene

IDBG-57308 (KCNMB1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015269	calcium-activated potassium channel activity
GO:0015459	potassium channel regulator activity

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0051592	response to calcium ion
GO:0071805	potassium ion transmembrane transport