Homo sapiens Gene: APOL1
Summary
InnateDB Gene IDBG-5737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOL1
Gene Name apolipoprotein L, 1
Synonyms APO-L; APOL; APOL-I; FSGS4;
Species Homo sapiens
Ensembl Gene ENSG00000100342
Encoded Proteins
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
apolipoprotein L, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36253010-36267530
Strand Forward strand
Band q12.3
Transcripts
ENST00000319136 ENSP00000317674
ENST00000397279 ENSP00000380449
ENST00000397278 ENSP00000380448
ENST00000422706 ENSP00000411507
ENST00000426053 ENSP00000388477
ENST00000422471 ENSP00000391206
ENST00000427990 ENSP00000391302
ENST00000439680 ENSP00000397141
ENST00000438034 ENSP00000404525
ENST00000433768 ENSP00000392514
ENST00000431184 ENSP00000392857
ENST00000475519
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006821 chloride transport
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0019835 cytolysis
GO:0031640 killing of cells of other organism
GO:0042157 lipoprotein metabolic process
GO:0045087 innate immune response
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031224 intrinsic component of membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Scavenging of heme from plasma pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
African trypanosomiasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14791
TrEMBL B1AH96 G8JL88 U5LGU2
UniProt Splice Variant
Entrez Gene 8542
UniGene Hs.114309 Hs.607747
RefSeq NM_145343 NM_003661 NM_001136540 NM_001136541 XM_005261796
HUGO HGNC:618
OMIM 603743
CCDS CCDS13925 CCDS13926 CCDS46702
HPRD 04774
IMGT
EMBL AF019225 AF305224 AF305428 AF323540 AF323543 AF323544 AF323545 AF323546 AF323547 AF323548 AK300454 BC143039 KC339295 Z82215
GenPept AAB81218 AAG53690 AAI43040 AAK11591 AAK20210 AAL09358 AGX24961 BAG62174 CAI22438 CAQ09089
RNA Seq Atlas 8542