InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOL1

Summary

InnateDB Protein

IDBP-5739.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOL1

Protein Name

apolipoprotein L, 1

Synonyms

APO-L; APOL; APOL-I; FSGS4;

Species

Homo sapiens

Ensembl Protein

ENSP00000317674

InnateDB Gene

IDBG-5737 (APOL1)

Protein Structure

UniProt Annotation

Function

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.

Subcellular Localization

Secreted.

Disease Associations

Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269PubMed:20635188, ECO:0000269PubMed:20647424}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0006821	chloride transport
GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0019835	cytolysis
GO:0031640	killing of cells of other organism
GO:0042157	lipoprotein metabolic process
GO:0045087	innate immune response
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031224	intrinsic component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0072562	blood microparticle