Homo sapiens Gene: MOGS
Summary
InnateDB Gene IDBG-57447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOGS
Gene Name mannosyl-oligosaccharide glucosidase
Synonyms CDG2B; CWH41; DER7; GCS1;
Species Homo sapiens
Ensembl Gene ENSG00000115275
Encoded Proteins
mannosyl-oligosaccharide glucosidase
mannosyl-oligosaccharide glucosidase
mannosyl-oligosaccharide glucosidase
mannosyl-oligosaccharide glucosidase
mannosyl-oligosaccharide glucosidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74461057-74465410
Strand Reverse strand
Band p13.1
Transcripts
ENST00000233616 ENSP00000233616
ENST00000409065 ENSP00000386493
ENST00000452063 ENSP00000388201
ENST00000448666 ENSP00000410992
ENST00000414701 ENSP00000396298
ENST00000462189
ENST00000462443
ENST00000489655
ENST00000486036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004573 mannosyl-oligosaccharide glucosidase activity
GO:0015926 glucosidase activity
Biological Process
GO:0006457 protein folding
GO:0006487 protein N-linked glycosylation
GO:0009311 oligosaccharide metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Er associated degradation (erad) pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516119
RefSeq NM_001146158 NM_006302
HUGO
OMIM
CCDS CCDS42700 CCDS54370
HPRD 03214
IMGT
EMBL
GenPept
RNA Seq Atlas