Homo sapiens Gene: AUP1
Summary
InnateDB Gene IDBG-57682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AUP1
Gene Name ancient ubiquitous protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115307
Encoded Proteins
ancient ubiquitous protein 1
ancient ubiquitous protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74526645-74529939
Strand Reverse strand
Band p13.1
Transcripts
ENST00000377526 ENSP00000366748
ENST00000425118 ENSP00000403430
ENST00000463900
ENST00000466894
ENST00000486234
ENST00000462297
ENST00000464887
ENST00000472800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 43 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_181575
HUGO
OMIM
CCDS CCDS42702
HPRD 03892
IMGT
EMBL
GenPept
RNA Seq Atlas