Version 5.4
Homo sapiens Gene: MAPKAPK5
Summary
InnateDB Gene IDBG-57774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPKAPK5
Gene Name mitogen-activated protein kinase-activated protein kinase 5
Synonyms MAPKAP-K5; MK-5; MK5; PRAK
Species Homo sapiens
Ensembl Gene ENSG00000089022
Encoded Proteins
IDBP-597299
mitogen-activated protein kinase-activated protein kinase 5
IDBP-806729
mitogen-activated protein kinase-activated protein kinase 5
IDBP-601335
mitogen-activated protein kinase-activated protein kinase 5
IDBP-596145
mitogen-activated protein kinase-activated protein kinase 5
IDBP-806733
mitogen-activated protein kinase-activated protein kinase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:111841978-111896539
Strand Forward strand
Band q24.12
Transcripts
ENST00000550735 ENSP00000449667
ENST00000547305 ENSP00000473541
ENST00000553053 ENSP00000448408
ENST00000546394
ENST00000551404 ENSP00000449381
ENST00000549875 ENSP00000473467
ENST00000552111
ENST00000547067
ENST00000547915
ENST00000602983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0009103 lipopolysaccharide biosynthetic process
GO:0032007 negative regulation of TOR signaling
GO:0046777 protein autophosphorylation
GO:0090400 stress-induced premature senescence
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029454
View Gene Order
ENSBTAG00000009346
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL R4GN33
UniProt Splice Variant
Entrez Gene 8550
UniGene
RefSeq NM_003668 NM_139078 XM_005253976
HUGO HGNC:6889
OMIM 606723
CCDS CCDS44975 CCDS44976
HPRD
IMGT
EMBL AC003029
GenPept
RNA Seq Atlas 8550

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca