InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPKAPK5

Summary

InnateDB Protein

IDBP-597299.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPKAPK5

Protein Name

mitogen-activated protein kinase-activated protein kinase 5

Synonyms

MAPKAP-K5; MK-5; MK5; PRAK;

Species

Homo sapiens

Ensembl Protein

ENSP00000449667

InnateDB Gene

IDBG-57774 (MAPKAPK5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0009103	lipopolysaccharide biosynthetic process
GO:0032007	negative regulation of TOR signaling
GO:0046777	protein autophosphorylation
GO:0090400	stress-induced premature senescence

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt