Homo sapiens Gene: ATP6V0E1
Summary
InnateDB Gene IDBG-57918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V0E1
Gene Name ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Synonyms ATP6H; ATP6V0E; M9.2; Vma21; Vma21p;
Species Homo sapiens
Ensembl Gene ENSG00000113732
Encoded Proteins
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:172983757-173035445
Strand Forward strand
Band q35.1
Transcripts
ENST00000265093 ENSP00000265093
ENST00000519374 ENSP00000429690
ENST00000519911 ENSP00000430896
ENST00000517669 ENSP00000427941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0042625 ATPase activity, coupled to transmembrane movement of ions
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006879 cellular iron ion homeostasis
GO:0007035 vacuolar acidification
GO:0008152 metabolic process
GO:0008286 insulin receptor signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0016049 cell growth
GO:0033572 transferrin transport
GO:0043200 response to amino acid
GO:0051701 interaction with host
GO:0055085 transmembrane transport
GO:0090382 phagosome maturation
Cellular Component
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0033179 proton-transporting V-type ATPase, V0 domain
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by Insulin receptor pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
KEGG
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O15342
TrEMBL
UniProt Splice Variant
Entrez Gene 8992
UniGene
RefSeq NM_003945
HUGO HGNC:863
OMIM 603931
CCDS CCDS4383
HPRD 04894
IMGT
EMBL AK312068 BC119714 BC119715 CH471062 CR456856 CR542131 Y15286
GenPept AAI19715 AAI19716 BAG35004 CAA75571 CAG33137 CAG46928 EAW61417 EAW61418
RNA Seq Atlas 8992