InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V0E1

Summary

InnateDB Protein

IDBP-473784.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0E1

Protein Name

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

Synonyms

ATP6H; ATP6V0E; M9.2; Vma21; Vma21p;

Species

Homo sapiens

Ensembl Protein

ENSP00000427941

InnateDB Gene

IDBG-57918 (ATP6V0E1)

Protein Structure

UniProt Annotation

Function

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:17350184}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0042625	ATPase activity, coupled to transmembrane movement of ions
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0007035	vacuolar acidification
GO:0008152	metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0016049	cell growth
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain