Homo sapiens Gene: DLX4
Summary
InnateDB Gene IDBG-57924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX4
Gene Name distal-less homeobox 4
Synonyms BP1; DLX7; DLX8; DLX9;
Species Homo sapiens
Ensembl Gene ENSG00000108813
Encoded Proteins
distal-less homeobox 4
distal-less homeobox 4
distal-less homeobox 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49968970-49974959
Strand Forward strand
Band q21.33
Transcripts
ENST00000240306 ENSP00000240306
ENST00000411890 ENSP00000410622
ENST00000503410
ENST00000505318
ENST00000503276
ENST00000611342 ENSP00000480366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.172648 Hs.591167
RefSeq NM_001934 NM_138281
HUGO
OMIM
CCDS CCDS11555 CCDS45728
HPRD 03553
IMGT
EMBL
GenPept
RNA Seq Atlas