Version 5.4
Homo sapiens Gene: DLX4
Summary
InnateDB Gene IDBG-57924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX4
Gene Name distal-less homeobox 4
Synonyms BP1; DLX7; DLX8; DLX9
Species Homo sapiens
Ensembl Gene ENSG00000108813
Encoded Proteins
IDBP-57926
distal-less homeobox 4
IDBP-380883
distal-less homeobox 4
IDBP-806320
distal-less homeobox 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49968970-49974959
Strand Forward strand
Band q21.33
Transcripts
ENST00000240306 ENSP00000240306
ENST00000411890 ENSP00000410622
ENST00000503410
ENST00000505318
ENST00000503276
ENST00000611342 ENSP00000480366
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020871
View Gene Order
ENSBTAG00000007353
Not yet available
Cross-References
SwissProt Q92988
TrEMBL
UniProt Splice Variant
Entrez Gene 1748
UniGene Hs.172648 Hs.591167
RefSeq NM_001934 NM_138281
HUGO HGNC:2917
OMIM 601911
CCDS CCDS11555 CCDS45728
HPRD
IMGT
EMBL AF028235 AF254115 AF452638 BC005812 BC014419 BC016145 BT006978 CH471109 U31762 U73328
GenPept AAC14398 AAC50942 AAC51171 AAG31975 AAH05812 AAH14419 AAH16145 AAL99503 AAP35624 EAW94651 EAW94653 EAW94654 EAW94655
RNA Seq Atlas 1748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca