Version 5.4
Homo sapiens Gene: HK2
Summary
InnateDB Gene IDBG-58047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HK2
Gene Name hexokinase 2
Synonyms HKII; HXK2;
Species Homo sapiens
Ensembl Gene ENSG00000159399
Encoded Proteins
IDBP-58049
hexokinase 2
IDBP-295466
hexokinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74833981-74893359
Strand Forward strand
Band p12
Transcripts
ENST00000290573 ENSP00000290573
ENST00000409174 ENSP00000387140
ENST00000472302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0008865 fructokinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
Biological Process
GO:0001678 cellular glucose homeostasis
GO:0002931 response to ischemia
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0007595 lactation
GO:0008637 apoptotic mitochondrial changes
GO:0008645 hexose transport
GO:0015758 glucose transport
GO:0044281 small molecule metabolic process
GO:0046324 regulation of glucose import
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000000628
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000013108
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00051
Fructose and mannose metabolism pathway
hsa00052
Galactose metabolism pathway
hsa00500
Starch and sucrose metabolism pathway
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00524
Butirosin and neomycin biosynthesis pathway
hsa04910
Insulin signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
INOH website
Fructose Mannose metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Aminosugars metabolism pathway
PID BIOCARTA
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL E9PB90 Q09LL6 Q53QX9 Q7Z7Q6
UniProt Splice Variant
Entrez Gene 3099
UniGene Hs.591588 Hs.599966
RefSeq NM_000189
HUGO HGNC:4923
OMIM 601125
CCDS CCDS1956
HPRD 03080
IMGT
EMBL AC019069 AC104135 DQ871602 Z46360
GenPept AAY24209 ABI49509 CAA86482
RNA Seq Atlas 3099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca