InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HK2

Summary

InnateDB Protein

IDBP-58049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HK2

Protein Name

hexokinase 2

Synonyms

HKII; HXK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000290573

InnateDB Gene

IDBG-58047 (HK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0008865	fructokinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0002931	response to ischemia
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0007595	lactation
GO:0008637	apoptotic mitochondrial changes
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0044281	small molecule metabolic process
GO:0046324	regulation of glucose import
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0055085	transmembrane transport