Version 5.4
Homo sapiens Gene: CRNKL1
Summary
InnateDB Gene IDBG-58090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRNKL1
Gene Name crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101343
Encoded Proteins
IDBP-58092
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
IDBP-58094
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
IDBP-480574
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
IDBP-476022
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
IDBP-590986
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. This gene is similar in sequence to crn and encodes a protein which can localize to pre-mRNA splicing complexes in the nucleus. The encoded protein, which contains many tetratricopeptide repeats, is required for pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:20034368-20056046
Strand Reverse strand
Band p11.23
Transcripts
ENST00000377327 ENSP00000366544
ENST00000377340 ENSP00000366557
ENST00000490910 ENSP00000429226
ENST00000496549 ENSP00000428436
ENST00000521379
ENST00000490258
ENST00000536226 ENSP00000440733
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001767
View Gene Order
ENSBTAG00000008472
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9BZJ0
TrEMBL
UniProt Splice Variant
Entrez Gene 51340
UniGene Hs.171342 Hs.661545
RefSeq NM_001278628 NM_001278625 NM_001278626 NM_001278627 NM_016652
HUGO HGNC:15762
OMIM 610952
CCDS CCDS63238 CCDS33446 CCDS63239
HPRD 09898
IMGT
EMBL AF111802 AF255443 AF318302 AF318303 AF318304 AF318305 AK022908 AK023246 AK023728 AK292799 AL035454
GenPept AAF65571 AAK01924 AAK01925 AAK01926 AAK01927 AAL39004 BAB14303 BAB14485 BAB14659 BAF85488 CAI42113
RNA Seq Atlas 51340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca