Version 5.4
Homo sapiens Protein: CRNKL1
Summary
InnateDB Protein IDBP-590986.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRNKL1
Protein Name crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000440733
InnateDB Gene IDBG-58090 (CRNKL1)
Protein Structure
UniProt Annotation
Function Involved in pre-mRNA splicing process.
Subcellular Localization Nucleus speckle. Cytoplasm. Note=Colocalizes with core spliceosomal snRNP proteins. Also diffusely expressed in cytoplasm.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in testis. Not expressed in brain and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR003107 HAT (Half-A-TPR) repeat
IPR008847 Suppressor of forked
IPR013026 Tetratricopeptide repeat-containing domain
PFAM PF02184
PF05843
PRINTS
PIRSF
SMART SM00386
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZJ0
PhosphoSite PhosphoSite-Q9BZJ0
TrEMBL
UniProt Splice Variant
Entrez Gene 51340
UniGene Hs.661545
RefSeq NP_001265557
HUGO HGNC:15762
OMIM 610952
CCDS CCDS63238
HPRD 09898
IMGT
EMBL AF111802 AF255443 AF318302 AF318303 AF318304 AF318305 AK022908 AK023246 AK023728 AK292799 AL035454
GenPept AAF65571 AAK01924 AAK01925 AAK01926 AAK01927 AAL39004 BAB14303 BAB14485 BAB14659 BAF85488 CAI42113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca