Version 5.4
Homo sapiens Gene: SF3B2
Summary
InnateDB Gene IDBG-58371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SF3B2
Gene Name splicing factor 3b, subunit 2, 145kDa
Synonyms Cus1; SAP145; SF3b1; SF3B145; SF3b150
Species Homo sapiens
Ensembl Gene ENSG00000087365
Encoded Proteins
IDBP-58373
splicing factor 3b, subunit 2, 145kDa
IDBP-601880
splicing factor 3b, subunit 2, 145kDa
IDBP-587227
splicing factor 3b, subunit 2, 145kDa
IDBP-585641
splicing factor 3b, subunit 2, 145kDa
IDBP-598778
splicing factor 3b, subunit 2, 145kDa
IDBP-602272
splicing factor 3b, subunit 2, 145kDa
IDBP-595238
splicing factor 3b, subunit 2, 145kDa
IDBP-813168
splicing factor 3b, subunit 2, 145kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\'s branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66050729-66069308
Strand Forward strand
Band q13.1
Transcripts
ENST00000322535 ENSP00000318861
ENST00000529577
ENST00000534307
ENST00000528302 ENSP00000432655
ENST00000524627 ENSP00000435495
ENST00000533595 ENSP00000431908
ENST00000531041
ENST00000531589
ENST00000530322 ENSP00000431520
ENST00000524475 ENSP00000435765
ENST00000533421
ENST00000526653
ENST00000525207
ENST00000529994
ENST00000530981 ENSP00000436757
ENST00000534765
ENST00000610523 ENSP00000482986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 143 [view]
Protein-Protein 142 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005689 U12-type spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024853
View Gene Order
ENSBTAG00000002778
Not yet available
Pathways
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q13435
TrEMBL E9PIL8 E9PJ04 E9PJT3 E9PPJ0 H0YCG1
UniProt Splice Variant
Entrez Gene 10992
UniGene Hs.406423 Hs.635264 Hs.656571 Hs.690027
RefSeq NM_006842 XM_005273726
HUGO HGNC:10769
OMIM 605591
CCDS CCDS31612
HPRD
IMGT
EMBL AK290850 AK300016 AP006287 BC000401 BC007610 BC014125 BC053577 U41371
GenPept AAA97461 AAH00401 AAH07610 AAH14125 AAH53577 BAF83539 BAG61831
RNA Seq Atlas 102724664 10992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca