Version 5.4
Homo sapiens Gene: REG1A
Summary
InnateDB Gene IDBG-58452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REG1A
Gene Name regenerating islet-derived 1 alpha
Synonyms ICRF; P19; PSP; PSPS; PSPS1; PTP; REG
Species Homo sapiens
Ensembl Gene ENSG00000115386
Encoded Proteins
IDBP-58454
regenerating islet-derived 1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:79120362-79123419
Strand Forward strand
Band p12
Transcripts
ENST00000233735 ENSP00000233735
ENST00000488524
ENST00000461579
ENST00000485184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000059654
View Gene Order
Cross-References
SwissProt P05451
TrEMBL Q2TBE1
UniProt Splice Variant
Entrez Gene 5967
UniGene Hs.49407
RefSeq NM_002909
HUGO HGNC:9951
OMIM 167770
CCDS CCDS1964
HPRD
IMGT
EMBL AC017004 AF172331 BC005350 BC110438 BC118621 CH471053 J05412 M18963 M27189 M27190
GenPept AAA36558 AAA36559 AAA60545 AAA60546 AAD51330 AAH05350 AAI10439 AAI18622 AAX88842 EAW99576 EAW99578
RNA Seq Atlas 5967

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca