Homo sapiens Gene: TPCN1
Summary
InnateDB Gene IDBG-58610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPCN1
Gene Name two pore segment channel 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186815
Encoded Proteins
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
two pore segment channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113221050-113298585
Strand Forward strand
Band q24.13
Transcripts
ENST00000335509 ENSP00000335300
ENST00000392569 ENSP00000376350
ENST00000428632
ENST00000552642 ENSP00000447806
ENST00000547275 ENSP00000449560
ENST00000552985 ENSP00000447569
ENST00000550873 ENSP00000447073
ENST00000551096 ENSP00000447263
ENST00000551099 ENSP00000447181
ENST00000552897 ENSP00000449944
ENST00000550785 ENSP00000448083
ENST00000549279 ENSP00000448704
ENST00000552077
ENST00000552542 ENSP00000446767
ENST00000548465 ENSP00000448561
ENST00000546781 ENSP00000449564
ENST00000551127
ENST00000546503
ENST00000550543
ENST00000547955 ENSP00000448010
ENST00000546907
ENST00000546787
ENST00000541517 ENSP00000438125
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0072345 NAADP-sensitive calcium-release channel activity
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524763 Hs.622368 Hs.719545
RefSeq NM_001143819 NM_001301214 NM_017901 XM_005253906 XM_006719465
HUGO
OMIM
CCDS CCDS31908 CCDS44985
HPRD 18217
IMGT
EMBL
GenPept
RNA Seq Atlas