InnateDB Protein
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IDBP-604153.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TPCN1
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Protein Name
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two pore segment channel 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000448083
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InnateDB Gene
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IDBG-58610 (TPCN1)
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Protein Structure
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Function |
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. {ECO:0000269PubMed:19620632}.
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Subcellular Localization |
Lysosome membrane {ECO:0000269PubMed:19620632}; Multi-pass membrane protein {ECO:0000269PubMed:19620632}. Endosome membrane {ECO:0000269PubMed:19620632}; Multi-pass membrane protein {ECO:0000269PubMed:19620632}.
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Disease Associations |
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Tissue Specificity |
Highest expression found in the heart and kidney, and lowest expression found in the spleen. {ECO:0000269PubMed:10574461}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005821
Ion transport domain
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PFAM |
PF00520
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULQ1
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PhosphoSite |
PhosphoSite-Q9ULQ1
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TrEMBL |
F8W1L6
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UniProt Splice Variant |
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Entrez Gene |
53373
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UniGene |
Hs.719545
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RefSeq |
NP_001288143
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HUGO |
HGNC:18182
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OMIM |
609666
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CCDS |
CCDS44985
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HPRD |
18217
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IMGT |
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EMBL |
AB032995
AC010178
AC089999
AC127004
AK057414
AK075071
AK296268
AY083666
BC136795
BC136796
BC150203
BC152423
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GenPept |
AAI36796
AAI36797
AAI50204
AAI52424
AAM01199
BAA86483
BAC11385
BAH12298
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