Version 5.4
Homo sapiens Gene: SPRED1
Summary
InnateDB Gene IDBG-5867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRED1
Gene Name sprouty-related, EVH1 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166068
Encoded Proteins
IDBP-5869
sprouty-related, EVH1 domain containing 1
IDBP-595944
sprouty-related, EVH1 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:38252326-38357249
Strand Forward strand
Band q14
Transcripts
ENST00000299084 ENSP00000299084
ENST00000561205
ENST00000561317 ENSP00000453680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010923 negative regulation of phosphatase activity
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311 regulation of protein deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005901 caveola
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027351
View Gene Order
ENSBTAG00000032518
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL H0YMN8
UniProt Splice Variant
Entrez Gene 161742
UniGene Hs.525781 Hs.611670 Hs.629760
RefSeq NM_152594 XM_005254202 XM_005254203
HUGO HGNC:20249
OMIM 609291
CCDS CCDS32193
HPRD 11601
IMGT
EMBL AC069381
GenPept
RNA Seq Atlas 161742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca