InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPRED1

Summary

InnateDB Protein

IDBP-5869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPRED1

Protein Name

sprouty-related, EVH1 domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299084

InnateDB Gene

IDBG-5867 (SPRED1)

Protein Structure

UniProt Annotation

Function

Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16115197}; Peripheral membrane protein {ECO:0000269PubMed:16115197}. Membrane, caveola {ECO:0000269PubMed:16115197}; Peripheral membrane protein {ECO:0000269PubMed:16115197}. Nucleus {ECO:0000269PubMed:16115197}. Note=Localized in cholesterol-rich membrane raft/caveola fractions.

Disease Associations

Neurofibromatosis 1-like syndrome (NFLS) [MIM:611431]: A disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity. {ECO:0000269PubMed:17704776, ECO:0000269PubMed:19443465, ECO:0000269PubMed:20108422, ECO:0000269PubMed:21089071}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Weakly expressed in embryonic cell line HEK293. {ECO:0000269PubMed:15580519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005173	stem cell factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0030291	protein serine/threonine kinase inhibitor activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010923	negative regulation of phosphatase activity
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311	regulation of protein deacetylation