Homo sapiens Gene: SDS
Summary
InnateDB Gene IDBG-58808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SDS
Gene Name serine dehydratase
Synonyms SDH;
Species Homo sapiens
Ensembl Gene ENSG00000135094
Encoded Proteins
serine dehydratase
serine dehydratase
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113392445-113426301
Strand Reverse strand
Band q24.13
Transcripts
ENST00000257549 ENSP00000257549
ENST00000553112
ENST00000552280 ENSP00000449833
ENST00000546639
ENST00000546785
ENST00000547342 ENSP00000449061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003941 L-serine ammonia-lyase activity
GO:0004794 L-threonine ammonia-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006520 cellular amino acid metabolic process
GO:0006565 L-serine catabolic process
GO:0042866 pyruvate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glycine, serine and threonine metabolism pathway
Cysteine and methionine metabolism pathway
Valine, leucine and isoleucine biosynthesis pathway
INOH
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8VXS0
UniProt Splice Variant
Entrez Gene 10993
UniGene
RefSeq NM_006843
HUGO HGNC:10691
OMIM 182128
CCDS CCDS9169
HPRD 01633
IMGT
EMBL AC010178
GenPept
RNA Seq Atlas 10993