Version 5.4
Homo sapiens Gene: SDS
Summary
InnateDB Gene IDBG-58808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SDS
Gene Name serine dehydratase
Synonyms SDH
Species Homo sapiens
Ensembl Gene ENSG00000135094
Encoded Proteins
IDBP-58810
serine dehydratase
IDBP-604246
serine dehydratase
IDBP-604255
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113392445-113426301
Strand Reverse strand
Band q24.13
Transcripts
ENST00000257549 ENSP00000257549
ENST00000553112
ENST00000552280 ENSP00000449833
ENST00000546639
ENST00000546785
ENST00000547342 ENSP00000449061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003941 L-serine ammonia-lyase activity
GO:0004794 L-threonine ammonia-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006520 cellular amino acid metabolic process
GO:0006565 L-serine catabolic process
GO:0042866 pyruvate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029597
View Gene Order
ENSBTAG00000031814
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00290
Valine, leucine and isoleucine biosynthesis pathway
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006843
HUGO
OMIM
CCDS CCDS9169
HPRD 01633
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca