Homo sapiens Gene: LHX5
Summary
InnateDB Gene IDBG-58868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX5
Gene Name LIM homeobox 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089116
Encoded Proteins
LIM homeobox 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:113462034-113472280
Strand Reverse strand
Band q24.13
Transcripts
ENST00000261731 ENSP00000261731
ENST00000557836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007267 cell-cell signaling
GO:0021527 spinal cord association neuron differentiation
GO:0021549 cerebellum development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0021879 forebrain neuron differentiation
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0042127 regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.302029 Hs.551307 Hs.709068
RefSeq NM_022363
HUGO
OMIM
CCDS CCDS9171
HPRD 09344
IMGT
EMBL
GenPept
RNA Seq Atlas