Version 5.4
Homo sapiens Gene: NPAS4
Summary
InnateDB Gene IDBG-58980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPAS4
Gene Name neuronal PAS domain protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174576
Encoded Proteins
IDBP-58982
neuronal PAS domain protein 4
IDBP-595630
neuronal PAS domain protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66421004-66426707
Strand Forward strand
Band q13.2
Transcripts
ENST00000311034 ENSP00000311196
ENST00000525148 ENSP00000433135
ENST00000524617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000045903
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000014925
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8IUM7
TrEMBL B7ZL81
UniProt Splice Variant
Entrez Gene 266743
UniGene Hs.256036
RefSeq NM_178864
HUGO HGNC:18983
OMIM 608554
CCDS CCDS8138
HPRD
IMGT
EMBL AB049469 AK094025 AK096253 AP001107 BC105001 BC105003 BC143630
GenPept AAI05002 AAI05004 AAI43631 BAC04271 BAC04738 BAC19830
RNA Seq Atlas 266743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca