Version 5.4
Homo sapiens Protein: NPAS4
Summary
InnateDB Protein IDBP-58982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPAS4
Protein Name neuronal PAS domain protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000311196
InnateDB Gene IDBG-58980 (NPAS4)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene. {ECO:0000269PubMed:14701734}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Brain. {ECO:0000269PubMed:14701734}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR000014 PAS domain
IPR013655 PAS fold-3
PFAM PF13188
PF13426
PF08447
PRINTS
PIRSF
SMART SM00091
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUM7
PhosphoSite PhosphoSite-Q8IUM7
TrEMBL
UniProt Splice Variant
Entrez Gene 266743
UniGene Hs.256036
RefSeq NP_849195
HUGO HGNC:18983
OMIM 608554
CCDS CCDS8138
HPRD 12260
IMGT
EMBL AB049469 AK094025 AK096253 BC105001 BC105003
GenPept AAI05002 AAI05004 BAC04271 BAC04738 BAC19830

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca