Homo sapiens Gene: AP2S1
Summary
InnateDB Gene IDBG-59076.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP2S1
Gene Name adaptor-related protein complex 2, sigma 1 subunit
Synonyms AP17; CLAPS2; FBH3; FBHOk; HHC3;
Species Homo sapiens
Ensembl Gene ENSG00000042753
Encoded Proteins
adaptor-related protein complex 2, sigma 1 subunit
adaptor-related protein complex 2, sigma 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts. [provided by RefSeq, Jul 2008]
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46838136-46850992
Strand Reverse strand
Band q13.32
Transcripts
ENST00000263270 ENSP00000263270
ENST00000352203 ENSP00000263271
ENST00000599990 ENSP00000471340
ENST00000601498 ENSP00000470176
ENST00000593442 ENSP00000472080
ENST00000597421
ENST00000597020 ENSP00000470235
ENST00000600964
ENST00000601649 ENSP00000470898
ENST00000598027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030100 regulation of endocytosis
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048268 clathrin coat assembly
GO:0050690 regulation of defense response to virus by virus
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030122 AP-2 adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
PCP/CE pathway pathway
MHC class II antigen presentation pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
WNT5A-dependent internalization of FZD4 pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by EGFR pathway
Axon guidance pathway
Signal Transduction pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Nef Mediated CD8 Down-regulation pathway
Recycling pathway of L1 pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Retrograde neurotrophin signalling pathway
L1CAM interactions pathway
Nef Mediated CD4 Down-regulation pathway
EPH-ephrin mediated repulsion of cells pathway
HIV Infection pathway
EGFR downregulation pathway
EPH-Ephrin signaling pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
KEGG
Endocytosis pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001301076 NM_001301078 NM_001301081 NM_004069 NM_021575
HUGO
OMIM
CCDS CCDS12693 CCDS33062
HPRD 03762
IMGT
EMBL
GenPept
RNA Seq Atlas