Version 5.4
Homo sapiens Gene: NKX2-2
Summary
InnateDB Gene IDBG-59106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NKX2-2
Gene Name NK2 homeobox 2
Synonyms NKX2.2; NKX2B
Species Homo sapiens
Ensembl Gene ENSG00000125820
Encoded Proteins
IDBP-59108
NK2 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:21511010-21514026
Strand Reverse strand
Band p11.22
Transcripts
ENST00000377142 ENSP00000366347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001159 core promoter proximal region DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0003323 type B pancreatic cell development
GO:0003326 pancreatic A cell fate commitment
GO:0003327 type B pancreatic cell fate commitment
GO:0003329 pancreatic PP cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007224 smoothened signaling pathway
GO:0007399 nervous system development
GO:0007420 brain development
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0014070 response to organic cyclic compound
GO:0021522 spinal cord motor neuron differentiation
GO:0021529 spinal cord oligodendrocyte cell differentiation
GO:0021530 spinal cord oligodendrocyte cell fate specification
GO:0021554 optic nerve development
GO:0030154 cell differentiation
GO:0031018 endocrine pancreas development
GO:0032570 response to progesterone
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048565 digestive tract development
GO:0048665 neuron fate specification
GO:0048708 astrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060580 ventral spinal cord interneuron fate determination
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027434
View Gene Order
ENSBTAG00000010277
Not yet available
Pathways
NETPATH
REACTOME
REACT_13650
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Cross-References
SwissProt O95096
TrEMBL
UniProt Splice Variant
Entrez Gene 4821
UniGene Hs.516922
RefSeq NM_002509 XM_006723566
HUGO HGNC:7835
OMIM 604612
CCDS CCDS13145
HPRD
IMGT
EMBL AF019414 AF019415 AL133325 BC075092 BC075093
GenPept AAC83132 AAH75092 AAH75093 CAC00770
RNA Seq Atlas 4821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca