Version 5.4
Homo sapiens Gene: FOXA2
Summary
InnateDB Gene IDBG-59234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXA2
Gene Name forkhead box A2
Synonyms HNF3B; TCF3B
Species Homo sapiens
Ensembl Gene ENSG00000125798
Encoded Proteins
IDBP-59236
forkhead box A2
IDBP-369092
forkhead box A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20483781
FOXA2 is expressed selectively in the respiratory epithelium where it plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation.
InnateDB Annotation from Orthologs
Summary
PMID 20483781
[Mus musculus] Foxa2 is expressed selectively in the respiratory epithelium where it plays a critical role in regulating genetic programs influencing Th2 cell-mediated pulmonary inflammation.
Entrez Gene
Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:22581005-22585455
Strand Reverse strand
Band p11.21
Transcripts
ENST00000377115 ENSP00000366319
ENST00000419308 ENSP00000400341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0001701 in utero embryonic development
GO:0001705 ectoderm formation
GO:0001708 cell fate specification
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0008344 adult locomotory behavior
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0016568 chromatin modification
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0021533 cell differentiation in hindbrain
GO:0021904 dorsal/ventral neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030193 regulation of blood coagulation
GO:0030324 lung development
GO:0031018 endocrine pancreas development
GO:0032525 somite rostral/caudal axis specification
GO:0033132 negative regulation of glucokinase activity
GO:0040019 positive regulation of embryonic development
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0048468 cell development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048665 neuron fate specification
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448 connective tissue development
GO:0070741 response to interleukin-6
GO:0071542 dopaminergic neuron differentiation
GO:0090009 primitive streak formation
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000543 positive regulation of gastrulation
GO:2000971 negative regulation of detection of glucose
GO:2000976 regulation of transcription from RNA polymerase II promoter involved in detection of glucose
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037025
View Gene Order
ENSBTAG00000012407
Not yet available
Pathways
NETPATH
REACTOME
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
hnf3pathway
FOXA transcription factor networks
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt Q9Y261
TrEMBL B0ZTD4
UniProt Splice Variant
Entrez Gene 3170
UniGene Hs.155651
RefSeq NM_021784 NM_153675 XM_006723562
HUGO HGNC:5022
OMIM 600288
CCDS CCDS46585 CCDS13147
HPRD 02618
IMGT
EMBL AB028021 AF147787 AF176110 AL121722 BC006545 BC011780 BC019288 CH471133 EU402966
GenPept AAD41081 AAD51978 AAH06545 AAH11780 AAH19288 ACA06111 BAA78106 CAB89773 EAX10175
RNA Seq Atlas 3170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca