Homo sapiens Protein: FOXA2
Summary
InnateDB Protein IDBP-369092.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXA2
Protein Name forkhead box A2
Synonyms HNF3B; TCF3B;
Species Homo sapiens
Ensembl Protein ENSP00000400341
InnateDB Gene IDBG-59234 (FOXA2)
Protein Structure
UniProt Annotation
Function Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:14500912}. Cytoplasm {ECO:0000269PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0001701 in utero embryonic development
GO:0001705 ectoderm formation
GO:0001708 cell fate specification
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0008344 adult locomotory behavior
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0016568 chromatin modification
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0021533 cell differentiation in hindbrain
GO:0021904 dorsal/ventral neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030193 regulation of blood coagulation
GO:0030324 lung development
GO:0031018 endocrine pancreas development
GO:0032525 somite rostral/caudal axis specification
GO:0033132 negative regulation of glucokinase activity
GO:0040019 positive regulation of embryonic development
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0048468 cell development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048665 neuron fate specification
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448 connective tissue development
GO:0070741 response to interleukin-6
GO:0071542 dopaminergic neuron differentiation
GO:0090009 primitive streak formation
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000543 positive regulation of gastrulation
GO:2000971 negative regulation of detection of glucose
GO:2000976 regulation of transcription from RNA polymerase II promoter involved in detection of glucose
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001766 Transcription factor, fork head
IPR013638 Fork-head N-terminal
IPR018533 Forkhead box protein, C-terminal
PFAM PF00250
PF08430
PF09354
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y261
PhosphoSite PhosphoSite-Q9Y261
TrEMBL B0ZTD4
UniProt Splice Variant
Entrez Gene 3170
UniGene Hs.155651
RefSeq NP_068556
HUGO HGNC:5022
OMIM 600288
CCDS CCDS46585
HPRD 02618
IMGT
EMBL AB028021 AF147787 AF176110 AL121722 BC006545 BC011780 BC019288 CH471133 EU402966
GenPept AAD41081 AAD51978 AAH06545 AAH11780 AAH19288 ACA06111 BAA78106 CAB89773 EAX10175