Version 5.4
| Homo sapiens Gene: ATP1B3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-59280.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ATP1B3 | ||||||||||||||||||
| Gene Name | ATPase, Na+/K+ transporting, beta 3 polypeptide | ||||||||||||||||||
| Synonyms | ATPB-3; CD298 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000069849 | ||||||||||||||||||
| Encoded Proteins |
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+/K+ transporting, beta 3 polypeptide
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 3:141876124-141926514 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q23 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Basigin interactions pathway
Cell surface interactions at the vascular wall pathway
Ion transport by P-type ATPases pathway
Transmembrane transport of small molecules pathway
Ion channel transport pathway
Hemostasis pathway
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| KEGG |
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
Protein digestion and absorption pathway
Carbohydrate digestion and absorption pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.608705 | ||||||||||||||||||
| RefSeq | NM_001679 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS3121 | ||||||||||||||||||
| HPRD | 03521 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||