InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp1b3

Summary

InnateDB Gene

IDBG-191962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1b3

Gene Name

ATPase, Na+/K+ transporting, beta 3 polypeptide

Synonyms

AA409958; AI664000; AW212096

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032412

Encoded Proteins

IDBP-191964

ATPase, Na+/K+ transporting, beta 3 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069849:
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:96332655-96364442

Strand

Reverse strand

Band

E3.3

Transcripts

ENSMUST00000034983	ENSMUSP00000034983
ENSMUST00000190045
ENSMUST00000187341

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding

Biological Process

GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0030001	metal ion transport
GO:0035725	sodium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome