Version 5.4
Homo sapiens Gene: LY86
Summary
InnateDB Gene IDBG-59283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LY86
Gene Name lymphocyte antigen 86
Synonyms dJ80N2.1; MD-1; MMD-1
Species Homo sapiens
Ensembl Gene ENSG00000112799
Encoded Proteins
IDBP-59285
lymphocyte antigen 86
IDBP-59287
lymphocyte antigen 86
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15852007
LY86 and CD180 interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligand.
InnateDB Annotation from Orthologs
Summary
PMID 20534476
[Mus musculus] Ly86 (MD-1) complexes with Toll-like receptor homolog Cd180 (RP105) to regulate the Ly96 (MD-2)/Tlr4-mediated lipopolysaccharide (LPS) response. Soluble Ly86 alone, in addition to its complex with Cd180, can regulate host LPS sensitivity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:6588108-6654983
Strand Forward strand
Band p25.1
Transcripts
ENST00000379953 ENSP00000369286
ENST00000230568 ENSP00000230568
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0008283 cell proliferation
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021423
View Gene Order
ENSBTAG00000031444
Not yet available
Pathways
NETPATH
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O95711
TrEMBL
UniProt Splice Variant
Entrez Gene 9450
UniGene Hs.612651
RefSeq NM_004271 XM_006715273
HUGO HGNC:16837
OMIM 605241
CCDS CCDS4498
HPRD
IMGT
EMBL AB020499 AF057178 AL031123 BC038846
GenPept AAC98152 AAH38846 BAA76410 CAB76262
RNA Seq Atlas 9450

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca