InnateDB Protein
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IDBP-59285.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LY86
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Protein Name
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lymphocyte antigen 86
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Synonyms
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dJ80N2.1; MD-1; MMD-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369286
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InnateDB Gene
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IDBG-59283 (LY86)
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Protein Structure
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Function |
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
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Disease Associations |
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Tissue Specificity |
Highly expressed in B-cells, monocytes and tonsil.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003172
MD-2-related lipid-recognition domain
IPR014756
Immunoglobulin E-set
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PFAM |
PF02221
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PRINTS |
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PIRSF |
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SMART |
SM00737
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TIGRFAMs |
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Modification |
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SwissProt |
O95711
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PhosphoSite |
PhosphoSite-O95711
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9450
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UniGene |
Hs.612651
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RefSeq |
XP_006715336
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HUGO |
HGNC:16837
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OMIM |
605241
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CCDS |
CCDS4498
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HPRD |
05578
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IMGT |
|
EMBL |
AB020499
AF057178
AL031123
BC038846
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GenPept |
AAC98152
AAH38846
BAA76410
CAB76262
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