InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE6B

Summary

InnateDB Gene

IDBG-5946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE6B

Gene Name

phosphodiesterase 6B, cGMP-specific, rod, beta

Synonyms

CSNB3; CSNBAD2; PDEB; rd1; RP40

Species

Homo sapiens

Ensembl Gene

ENSG00000133256

Encoded Proteins

IDBP-5948

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-360614

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-484508

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-475158

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-482431

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-474560

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-479976

phosphodiesterase 6B, cGMP-specific, rod, beta

IDBP-475247

phosphodiesterase 6B, cGMP-specific, rod, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:625584-670782

Strand

Forward strand

Band

p16.3

Transcripts

ENST00000255622	ENSP00000255622
ENST00000429163	ENSP00000406334
ENST00000496514	ENSP00000420295
ENST00000465426	ENSP00000418454
ENST00000474251
ENST00000487902	ENSP00000418256
ENST00000476034
ENST00000488061	ENSP00000420228
ENST00000467152
ENST00000460119
ENST00000471824	ENSP00000417852
ENST00000461490	ENSP00000417178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0008152	metabolic process
GO:0009583	detection of light stimulus
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0046037	GMP metabolic process
GO:0051480	cytosolic calcium ion homeostasis
GO:0060041	retina development in camera-type eye