InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NME2

Summary

InnateDB Gene

IDBG-59608.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME2

Gene Name

NME/NM23 nucleoside diphosphate kinase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000011052

Encoded Proteins

IDBP-59610

non-metastatic cells 2, protein (NM23B) expressed in

IDBP-244099

NME1-NME2 readthrough

IDBP-244111

non-metastatic cells 2, protein (NM23B) expressed in

IDBP-597625

non-metastatic cells 2, protein (NM23B) expressed in

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010] Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:51153590-51171744

Strand

Forward strand

Band

q21.33

Transcripts

ENST00000376392	ENSP00000365572
ENST00000393193	ENSP00000376889
ENST00000393183	ENSP00000376880
ENST00000555572	ENSP00000451932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	13 [view]
Protein-DNA	21 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0004673	protein histidine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019215	intermediate filament binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0043015	gamma-tubulin binding
GO:0046872	metal ion binding

Biological Process

GO:0002762	negative regulation of myeloid leukocyte differentiation
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014075	response to amine
GO:0015949	nucleobase-containing small molecule interconversion
GO:0018106	peptidyl-histidine phosphorylation
GO:0021766	hippocampus development
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045682	regulation of epidermis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051591	response to cAMP
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000091228

View Gene Order

ENSBTAG00000047186

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

INOH

INOH website

Folate metabolism pathway

INOH website

Purine nucleotides nucleosides metabolism pathway

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

P22392

TrEMBL

F6XY72 Q6FHN3

UniProt Splice Variant

Entrez Gene

654364

UniGene

RefSeq

NM_001018136 NM_001018137 NM_001018138 NM_001018139 NM_001198682 NM_002512

HUGO

HGNC:7850

OMIM

156491

CCDS

CCDS32682 CCDS11580 CCDS74107

HPRD

IMGT

EMBL

AC005839 AK313448 BC002476 BC095458 BC133029 BC133031 BT007045 CH471109 CR541718 DQ109675 EU794639 L16785 M36981 U29200 X58965

GenPept

AAA36369 AAA60228 AAA86745 AAH02476 AAH95458 AAI33030 AAI33032 AAP35694 AAZ82097 ACJ13693 BAG36237 CAB37870 CAG46519 EAW94564 EAW94567

RNA Seq Atlas

4831 654364