InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME2

Summary

InnateDB Protein

IDBP-244099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME2

Protein Name

NME1-NME2 readthrough

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376889

InnateDB Gene

IDBG-59608 (NME2)

Protein Structure

UniProt Annotation

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. {ECO:0000269PubMed:15249197, ECO:0000269PubMed:20946858, ECO:0000269PubMed:8392752}.

Subcellular Localization

Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:16442775}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	13 [view]
Protein-DNA	21 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0004673	protein histidine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019215	intermediate filament binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0043015	gamma-tubulin binding
GO:0046872	metal ion binding

Biological Process

GO:0002762	negative regulation of myeloid leukocyte differentiation
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014075	response to amine
GO:0015949	nucleobase-containing small molecule interconversion
GO:0018106	peptidyl-histidine phosphorylation
GO:0021766	hippocampus development
GO:0033574	response to testosterone
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045682	regulation of epidermis development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051591	response to cAMP
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery