Homo sapiens Gene: SLC34A1
Summary
InnateDB Gene IDBG-59893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC34A1
Gene Name solute carrier family 34 (sodium phosphate), member 1
Synonyms FRTS2; NAPI-3; NPHLOP1; NPT2; NPTIIa; SLC11; SLC17A2;
Species Homo sapiens
Ensembl Gene ENSG00000131183
Encoded Proteins
solute carrier family 34 (sodium phosphate), member 1
solute carrier family 34 (sodium phosphate), member 1
solute carrier family 34 (sodium phosphate), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177379235-177398848
Strand Forward strand
Band q35.3
Transcripts
ENST00000324417 ENSP00000321424
ENST00000504577 ENSP00000423733
ENST00000512593 ENSP00000423022
ENST00000507685
ENST00000513614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015293 symporter activity
GO:0015321 sodium-dependent phosphate transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001503 ossification
GO:0001822 kidney development
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0007584 response to nutrient
GO:0009100 glycoprotein metabolic process
GO:0010288 response to lead ion
GO:0032026 response to magnesium ion
GO:0032355 response to estradiol
GO:0033189 response to vitamin A
GO:0035864 response to potassium ion
GO:0042431 indole metabolic process
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0044341 sodium-dependent phosphate transport
GO:0045838 positive regulation of membrane potential
GO:0046686 response to cadmium ion
GO:0046689 response to mercury ion
GO:0046849 bone remodeling
GO:0051260 protein homooligomerization
GO:0055062 phosphate ion homeostasis
GO:0055085 transmembrane transport
GO:0060416 response to growth hormone
GO:0071107 response to parathyroid hormone
GO:0071248 cellular response to metal ion
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0072350 tricarboxylic acid metabolic process
GO:0072734 cellular response to staurosporine
GO:0097066 response to thyroid hormone
GO:0097187 dentinogenesis
GO:1901128 gentamycin metabolic process
GO:1901652 response to peptide
GO:1901684 arsenate ion transmembrane transport
GO:2000120 positive regulation of sodium-dependent phosphate transport
GO:2000187 positive regulation of phosphate transmembrane transport
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031226 intrinsic component of plasma membrane
GO:0031526 brush border membrane
GO:0031988 membrane-bounded vesicle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Type II Na+/Pi cotransporters pathway
Sodium-coupled phosphate cotransporters pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q06495
TrEMBL D6RCE5 Q05BP0 V9H0C2 V9H0H5
UniProt Splice Variant
Entrez Gene 6569
UniGene Hs.936
RefSeq NM_001167579 NM_003052 XM_005265974
HUGO HGNC:11019
OMIM 182309
CCDS CCDS54953 CCDS4418
HPRD 08918
IMGT
EMBL AC145098 AK298299 BC035294 CH471195 L13258 U56678 U56685
GenPept AAA36354 AAD14851 AAD14857 AAH35294 BAG60555 EAW85009
RNA Seq Atlas 6569