Homo sapiens Gene: CST11
Summary
InnateDB Gene IDBG-59915.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST11
Gene Name cystatin 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125831
Encoded Proteins
cystatin 11
cystatin 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:23450403-23452857
Strand Reverse strand
Band p11.21
Transcripts
ENST00000377009 ENSP00000366208
ENST00000377007 ENSP00000366206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0042742 defense response to bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q9H112
TrEMBL
UniProt Splice Variant
Entrez Gene 140880
UniGene Hs.128100
RefSeq NM_080830 NM_130794
HUGO HGNC:15959
OMIM 609731
CCDS CCDS13154 CCDS13155
HPRD
IMGT
EMBL AF335480 AF335481 AL096677 BC121079 BC121080 CH471133
GenPept AAI21080 AAI21081 AAL71991 AAL71992 CAI20158 CAI20159 EAX10146
RNA Seq Atlas 140880