Version 5.4
Homo sapiens Protein: CST11
Summary
InnateDB Protein IDBP-59919.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST11
Protein Name cystatin 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366206
InnateDB Gene IDBG-59915 (CST11)
Protein Structure
UniProt Annotation
Function Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. {ECO:0000269PubMed:12072414}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12072414}. Cytoplasm {ECO:0000269PubMed:12072414}. Note=Nuclear and cytoplasmic in the epididymis. Localized to the postacrosomal and tail regions of sperm. Probably localized to the outer surface of sperm.
Disease Associations
Tissue Specificity Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level). {ECO:0000269PubMed:12072414}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0042742 defense response to bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H112
PhosphoSite PhosphoSite-Q9H112
TrEMBL
UniProt Splice Variant
Entrez Gene 140880
UniGene Hs.128100
RefSeq NP_543020
HUGO HGNC:15959
OMIM 609731
CCDS CCDS13154
HPRD 16767
IMGT
EMBL AF335480 AF335481 AL096677 BC121079 BC121080 CH471133
GenPept AAI21080 AAI21081 AAL71991 AAL71992 CAI20158 CAI20159 EAX10146

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca