Version 5.4
| Homo sapiens Gene: CST8 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-59966.5 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | CST8 | ||||||
| Gene Name | cystatin 8 (cystatin-related epididymal specific) | ||||||
| Synonyms | CRES; CTES5 | ||||||
| Species | Homo sapiens | ||||||
| Ensembl Gene | ENSG00000125815 | ||||||
| Encoded Proteins |
cystatin 8 (cystatin-related epididymal specific)
cystatin 8 (cystatin-related epididymal specific)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined. [provided by RefSeq, Jul 2008] The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 20:23491101-23496018 | ||||||
| Strand | Forward strand | ||||||
| Band | p11.21 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||
| SwissProt | O60676 | ||||||
| TrEMBL | A2A2N0 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 10047 | ||||||
| UniGene | Hs.121602 | ||||||
| RefSeq | NM_001281730 NM_005492 XM_005260639 | ||||||
| HUGO | HGNC:2480 | ||||||
| OMIM | 608683 | ||||||
| CCDS | CCDS13156 | ||||||
| HPRD | 16366 | ||||||
| IMGT | |||||||
| EMBL | AF059244 AL109954 BC069496 BC105113 BC105119 | ||||||
| GenPept | AAC14707 AAH69496 AAI05114 AAI05120 CAB64234 | ||||||
| RNA Seq Atlas | 10047 | ||||||