Version 5.4
Homo sapiens Protein: CST8
Summary
InnateDB Protein IDBP-59968.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST8
Protein Name cystatin 8 (cystatin-related epididymal specific)
Synonyms CRES; CTES5;
Species Homo sapiens
Ensembl Protein ENSP00000246012
InnateDB Gene IDBG-59966 (CST8)
Protein Structure
UniProt Annotation
Function Performs a specialized role during sperm development and maturation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60676
PhosphoSite PhosphoSite-O60676
TrEMBL A2A2N0
UniProt Splice Variant
Entrez Gene 10047
UniGene Hs.121602
RefSeq NP_005483
HUGO HGNC:2480
OMIM 608683
CCDS CCDS13156
HPRD 16366
IMGT
EMBL AF059244 AL109954 BC069496 BC105113 BC105119
GenPept AAC14707 AAH69496 AAI05114 AAI05120 CAB64234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca