Homo sapiens Gene: CIT
Summary
InnateDB Gene IDBG-60008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CIT
Gene Name citron (rho-interacting, serine/threonine kinase 21)
Synonyms CRIK; STK21;
Species Homo sapiens
Ensembl Gene ENSG00000122966
Encoded Proteins
citron (rho-interacting, serine/threonine kinase 21)
citron (rho-interacting, serine/threonine kinase 21)
citron (rho-interacting, serine/threonine kinase 21)
citron (rho-interacting, serine/threonine kinase 21)
citron (rho-interacting, serine/threonine kinase 21)
citron rho-interacting serine/threonine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:119685790-119877291
Strand Reverse strand
Band q24.23
Transcripts
ENST00000261833 ENSP00000261833
ENST00000392521 ENSP00000376306
ENST00000392520 ENSP00000376305
ENST00000469414
ENST00000488203
ENST00000545913
ENST00000537607
ENST00000544872
ENST00000538073
ENST00000543324
ENST00000544800
ENST00000543239
ENST00000536008
ENST00000544588
ENST00000536325 ENSP00000443199
ENST00000546026 ENSP00000446105
ENST00000541841
ENST00000539413
ENST00000612548 ENSP00000482318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0046872 metal ion binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0007030 Golgi organization
GO:0007067 mitotic nuclear division
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0008064 regulation of actin polymerization or depolymerization
GO:0016358 dendrite development
GO:0035556 intracellular signal transduction
GO:0048699 generation of neurons
GO:0050774 negative regulation of dendrite morphogenesis
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0031985 Golgi cisterna
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 11113
UniGene Hs.119594 Hs.595215 Hs.673192 Hs.707600
RefSeq XM_005253829 NM_001206999 NM_007174
HUGO HGNC:1985
OMIM 605629
CCDS CCDS55891 CCDS9192
HPRD 09289
IMGT
EMBL
GenPept
RNA Seq Atlas 100302274 11113