Homo sapiens Gene: CACNG2
Summary
InnateDB Gene IDBG-6020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNG2
Gene Name calcium channel, voltage-dependent, gamma subunit 2
Synonyms MRD10;
Species Homo sapiens
Ensembl Gene ENSG00000166862
Encoded Proteins
calcium channel, voltage-dependent, gamma subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36563921-36703558
Strand Reverse strand
Band q12.3
Transcripts
ENST00000300105 ENSP00000300105
ENST00000480002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0006810 transport
GO:0007268 synaptic transmission
GO:0007528 neuromuscular junction development
GO:0019226 transmission of nerve impulse
GO:0042391 regulation of membrane potential
GO:0050877 neurological system process
GO:0051899 membrane depolarization
GO:0060081 membrane hyperpolarization
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016021 integral component of membrane
GO:0030666 endocytic vesicle membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Trafficking of AMPA receptors pathway
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
MAPK signaling pathway pathway
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y698
TrEMBL
UniProt Splice Variant
Entrez Gene 10369
UniGene Hs.607330
RefSeq NM_006078
HUGO HGNC:1406
OMIM 602911
CCDS CCDS13931
HPRD 04220
IMGT
EMBL AF096322 AL022313 AL031845 AL049749 BC069612 BC112297 BC112299 CR456414
GenPept AAD22738 AAH69612 AAI12298 AAI12300 CAG30300 CAI17986 CAI19227
RNA Seq Atlas 10369