Version 5.4
Homo sapiens Gene: CST2
Summary
InnateDB Gene IDBG-60301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST2
Gene Name cystatin SA
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170369
Encoded Proteins
IDBP-60303
cystatin SA
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:23823769-23826731
Strand Reverse strand
Band p11.21
Transcripts
ENST00000304725 ENSP00000307540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt P09228
TrEMBL
UniProt Splice Variant
Entrez Gene 1470
UniGene
RefSeq NM_001322
HUGO HGNC:2474
OMIM 123856
CCDS CCDS13161
HPRD
IMGT
EMBL AF319564 AL591074 BC062679 M19671 M19672 M19673
GenPept AAA36116 AAH62679 AAK11570 CAC94784
RNA Seq Atlas 1470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca