Version 5.4
Homo sapiens Protein: CST2
Summary
InnateDB Protein IDBP-60303.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST2
Protein Name cystatin SA
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000307540
InnateDB Gene IDBG-60301 (CST2)
Protein Structure
UniProt Annotation
Function Thiol protease inhibitor.
Subcellular Localization Secreted {ECO:0000269PubMed:20189825}.
Disease Associations
Tissue Specificity Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland. {ECO:0000269PubMed:11879580, ECO:0000269PubMed:20189825}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P09228
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1470
UniGene
RefSeq NP_001313
HUGO HGNC:2474
OMIM 123856
CCDS CCDS13161
HPRD 00461
IMGT
EMBL AF319564 AL591074 BC062679 M19671 M19672 M19673
GenPept AAA36116 AAH62679 AAK11570 CAC94784

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca