Homo sapiens Gene: AKAP1
Summary
InnateDB Gene IDBG-60341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP1
Gene Name A kinase (PRKA) anchor protein 1
Synonyms AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1; PPP1R43; PRKA1; SAKAP84; TDRD17;
Species Homo sapiens
Ensembl Gene ENSG00000121057
Encoded Proteins
A kinase (PRKA) anchor protein 1
A kinase (PRKA) anchor protein 1
A kinase (PRKA) anchor protein 1
A kinase (PRKA) anchor protein 1
A kinase (PRKA) anchor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:57085092-57121349
Strand Forward strand
Band q22
Transcripts
ENST00000337714 ENSP00000337736
ENST00000314126 ENSP00000314075
ENST00000481416 ENSP00000433212
ENST00000539273 ENSP00000443139
ENST00000574683 ENSP00000460209
ENST00000570423 ENSP00000458982
ENST00000576295 ENSP00000458378
ENST00000576591 ENSP00000460514
ENST00000572557 ENSP00000459895
ENST00000573085 ENSP00000460557
ENST00000572560 ENSP00000458370
ENST00000573326 ENSP00000461854
ENST00000575032 ENSP00000460762
ENST00000575186 ENSP00000461418
ENST00000572814 ENSP00000458164
ENST00000572156 ENSP00000459521
ENST00000571629 ENSP00000459968
ENST00000575322 ENSP00000459808
ENST00000621116 ENSP00000478212
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007596 blood coagulation
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463506 Hs.622098 Hs.690812
RefSeq NM_001242902 NM_001242903 NM_003488 XM_005257707 XM_005257709 XM_006722126 XM_006722127
HUGO
OMIM
CCDS CCDS11594
HPRD 03905
IMGT
EMBL
GenPept
RNA Seq Atlas