InnateDB: Systems Biology of the Innate Immune Response

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:57085092-57121349

Strand

Forward strand

Band

q22

Transcripts

ENST00000337714	ENSP00000337736
ENST00000314126	ENSP00000314075
ENST00000481416	ENSP00000433212
ENST00000539273	ENSP00000443139
ENST00000574683	ENSP00000460209
ENST00000570423	ENSP00000458982
ENST00000576295	ENSP00000458378
ENST00000576591	ENSP00000460514
ENST00000572557	ENSP00000459895
ENST00000573085	ENSP00000460557
ENST00000572560	ENSP00000458370
ENST00000573326	ENSP00000461854
ENST00000575032	ENSP00000460762
ENST00000575186	ENSP00000461418
ENST00000572814	ENSP00000458164
ENST00000572156	ENSP00000459521
ENST00000571629	ENSP00000459968
ENST00000575322	ENSP00000459808
ENST00000621116	ENSP00000478212

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007596

blood coagulation

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018428

View Gene Order

ENSBTAG00000025320

Not yet available

Pathways

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

vegfr1_2_pathway

Signaling events mediated by VEGFR1 and VEGFR2

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.463506 Hs.622098 Hs.690812

RefSeq

NM_001242902 NM_001242903 NM_003488 XM_005257707 XM_005257709 XM_006722126 XM_006722127

HUGO

OMIM

CCDS

CCDS11594

HPRD

03905

IMGT

EMBL

GenPept

RNA Seq Atlas