Version 5.4
Homo sapiens Gene: CORO1B
Summary
InnateDB Gene IDBG-60380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CORO1B
Gene Name coronin, actin binding protein, 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172725
Encoded Proteins
IDBP-60382
coronin, actin binding protein, 1B
IDBP-242686
coronin, actin binding protein, 1B
IDBP-587939
coronin, actin binding protein, 1B
IDBP-587180
coronin, actin binding protein, 1B
IDBP-812535
coronin, actin binding protein, 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67435510-67443821
Strand Reverse strand
Band q13.2
Transcripts
ENST00000341356 ENSP00000340211
ENST00000393893 ENSP00000377471
ENST00000453768
ENST00000537042 ENSP00000445330
ENST00000539724
ENST00000539970
ENST00000545016 ENSP00000438056
ENST00000545736
ENST00000616321 ENSP00000479949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0051015 actin filament binding
GO:0071933 Arp2/3 complex binding
Biological Process
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0031529 ruffle organization
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0035767 endothelial cell chemotaxis
GO:0042060 wound healing
GO:0051017 actin filament bundle assembly
GO:0090135 actin filament branching
GO:1902463 protein localization to cell leading edge
GO:2000394 positive regulation of lamellipodium morphogenesis
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0031252 cell leading edge
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024835
View Gene Order
ENSBTAG00000004783
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 57175
UniGene Hs.6191
RefSeq NM_001018070 NM_020441
HUGO HGNC:2253
OMIM 609849
CCDS CCDS8164
HPRD 16743
IMGT
EMBL
GenPept
RNA Seq Atlas 57175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca